Trust is a major component of starting any innovation program. At the Department of Health and Human Services, we strive to meet the American people and learn from them at every step. We are working diligently to build trusting relationships with previously underserved communities, including patients. Our grassroots approach to public health innovation informs our programs by listening to the experiences of the people we serve. We developed the Health+ methodology to tackle critical health challenges from COVID-19 to Sickle Cell to Lyme disease. Using design, data, and technology, we're empowering HHS to find solutions to the problems we face. Health+ harnesses human-centered design methods, open data, and crowdsourcing to catalyze innovation and secure an equitable and healthy future for all Americans. In this panel session, you'll hear about how Health+ is facilitating patient-centered innovations as part of the LymeX public-private partnership with the Steven & Alexandra Cohen Foundation and how to apply these design methods in your own projects. The panel will be moderated by Health+ Director and IT Specialist Alex Wilson. It will feature perspectives from the Chief Experience Officer working directly with individuals living with Lyme disease, the Steven & Alexandra Cohen Foundation, and the HHS Chief Data Scientist with direct lived experience.